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Merck

676491

VEGF Inducer, GS4012

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

Synonym(s):

VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012

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About This Item

Empirical Formula (Hill Notation):
C14H15NOS · xHCl
CAS Number:
328073-92-3
Molecular Weight:
245.34 (free base basis)
MDL number:
MFCD00550210
UNSPSC Code:
12352200
NACRES:
NA.51

Key Documents

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Product Name

VEGF Inducer, GS4012, A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

InChI key

CYZALCLQLHDAEC-UHFFFAOYSA-N

InChI

1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H

SMILES string

S(CCc2ccncc2)c1ccc(cc1)OC.Cl

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

DMSO: 200 mg/mL
methanol: 50 mg/mL
water: soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.

Other Notes

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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