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5.08436

AEBSF Hydrochloride

Name: AEBSF Hydrochloride
Brand: MM

≥97% (HPLC), serine proteases inhibitor, liquid

Sinónimos:

InSolution AEBSF, Hydrochloride, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl, AEBSF, HCl InSolution

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Fórmula empírica (notación de Hill):

C₈H₁₀FNO₂S · xHCl

Número CAS:

30827-99-7

Peso molecular:

203.23 (free base basis)

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00132962

Assay:

≥97% (HPLC)

Form:

liquid

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

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Propiedades

Nombre del producto

AEBSF Hydrochloride, InSolution, ≥97%, Specific, irreversible inhibitor of serine proteases

Quality Segment

100

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

storage temp.

−70°C

SMILES string

F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

Descripción

General description

Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPU_α) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications.

Biochem/physiol Actions

Reversible: no

Packaging

Packaged under inert gas

Physical form

A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride (Cat. No. 101500) in H₂O.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C.

Other Notes

Citron, M., et al. 1996. Neuron17, 171.
Ohkubo, I., et al. 1994. J. Biochem.116, 1182.
Mintz, G.R. 1993. BioPharm.6, 34.
Lawson, W.B., et al. 1982. Folia Haematol.109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.

Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c