- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper, tube, 100mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%
Copper, wire reel, 500m, diameter 0.5mm, annealed, 99.9%
Copper - O.F.H.C., foil, 25mm disks, thickness 0.7mm, half hard, 99.95+%
Copper - O.F.H.C., rod, 1000mm, diameter 3.15mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.010mm, hard, 99.95+%
Copper, wire reel, 2000m, diameter 0.075mm, annealed, 99.9%
Copper - O.F.H.C., sheet, 100x100mm, thickness 3.0mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.006mm, hard, 99.95+%
Copper, wire reel, 5m, diameter 1.0mm, as drawn, 99.99+%
Copper, wire reel, 50m, diameter 0.25mm, as drawn, 99.99+%
Copper - O.F.H.C., foil, 5m coil, thickness 0.1mm, hard, 99.95+%
Copper, tube, 500mm, outside diameter 0.75mm, inside diameter 0.23mm, wall thickness 0.26mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 10m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.5mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 25mm disks, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.125mm, hard, 99.95+%
Copper, tube, 500mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 10m coil, thickness 0.05mm, coil width 10mm, annealed, 99.95+%
Copper, wire reel, 100m, diameter 0.075mm, annealed, 99.9%
Copper - O.F.H.C., foil, 0.5m coil, thickness 0.05mm, hard, 99.95+%
Copper, tube, 200mm, outside diameter 3.0mm, inside diameter 1.2mm, wall thickness 0.9mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., foil, 25mm disks, thickness 1.0mm, half hard, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 3.2mm, inside diameter 2.4mm, wall thickness 0.4mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., sheet, 100x100mm, thickness 4.76mm, 99.95+%
Copper, wire reel, 5m, diameter 0.01mm, hard, 99.99%
Copper - O.F.H.C., rod, 200mm, diameter 50.0mm, as drawn, 99.95+%
Copper, wire reel, 100m, diameter 0.5mm, as drawn, 99.98+%
Copper, wire reel, 50m, diameter 0.15mm, annealed, silver plated, 99.9%