- A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells.
A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio) (2016-11-27)
Gisela Pachón-Peña, Conor Donnelly, Catalina Ruiz-Cañada, Adam Katz, Sonia Fernández-Veledo, Joan Vendrell, Robert Sackstein
PMID27888602
ABSTRACT
The clinical effectiveness of systemically administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM-hMSCs) natively lack endothelial binding capacity, but express a CD44 glycovariant containing N-linked sialyllactosamines that can be α(1,3)-fucosylated using fucosyltransferase-VI (FTVI) to enforce sLe
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