- Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.
Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2012-04-12)
Sóstenes Mistro, Isis de M Maciel, Rouseli G de Menezes, Zuinara P Maia, Robert T Schooley, Roberto Badaró
PMID22491505
ABSTRACT
This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI, .36-.64]); n = 1233), respectively.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Amphotericin B solubilized, powder, γ-irradiated, BioXtra, suitable for cell culture
Amphotericin B for microbiological assay, European Pharmacopoeia (EP) Reference Standard
Amphotericin B for peak identification, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Amphotericin B from Streptomyces sp., BioReagent, suitable for cell culture, ~80% (HPLC)
Sigma-Aldrich
Amphotericin B solution, 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture
Amphotericin B, European Pharmacopoeia (EP) Reference Standard