Agonist
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566660 Sigma-AldrichSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
444143 Sigma-AldrichMDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.
505419 Sigma-Aldrichα,β-methylene ATP - CAS 104809-20-3 - Calbiochem
540220 Sigma-AldrichPurmorphamine - CAS 483367-10-8 - Calbiochem
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).