MOUSE ANTI-HUMAN INSULIN MONOCLONAL ANTIBODY
- Document Type:
- Data Sheet
insulin antibody
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An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture.
- Alpha IR-3, a monoclonal antibody to the insulin-like growth factor I receptor which blocks insulin-like growth factor I binding and inhibits its activity, inhibits the binding of 125I-insulin-like growth factor I to MCF-7 cells (an estrogen dependent human breast carcinoma cell line) with an IC-50 of approximately 100 ng/ml. It also inhibits the growth of MCF-7 cells cultured in 5% calf serum with approximately the same IC-50. Inhibition of growth occurs both when cells are cultured in the presence and absence of estrogen and is more pronounced when cells are grown at a low density. These findings demonstrate a requirement for insulin-like growth factor I for optimal growth of MCF-7 cells and suggest that it is an autocrine growth factor in these cells.
- Document Type:
- Reference
- Product Catalog Number:
- MABS192
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MOUSE ANTI- INSULIN RECEPTOR (-SUBUNIT) MONOCLONAL ANTIBODY - 2000373
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2000373
- Product Catalog Number:
- MAB1137Z
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MOUSE ANTI- INSULIN RECEPTOR (-SUBUNIT) MONOCLONAL ANTIBODY - 2033621
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2033621
- Product Catalog Number:
- MAB1137Z
-
MOUSE ANTI- INSULIN RECEPTOR (-SUBUNIT) MONOCLONAL ANTIBODY - 2168242
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2168242
- Product Catalog Number:
- MAB1137
-
MOUSE ANTI- INSULIN RECEPTOR (-SUBUNIT) MONOCLONAL ANTIBODY - 1987034
- Document Type:
- Certificate of Analysis
- Lot Number:
- 1987034
- Product Catalog Number:
- MAB1137Z
-
MOUSE ANTI- INSULIN RECEPTOR (α-SUBUNIT) MONOCLONAL ANTIBODY - 2964790
- Document Type:
- Certificate of Analysis
- Lot Number:
- 2964790
- Product Catalog Number:
- MAB1137
-
MOUSE ANTI- INSULIN RECEPTOR (α-SUBUNIT) MONOCLONAL ANTIBODY
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3010012
- Product Catalog Number:
- MAB1137
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MOUSE ANTI- INSULIN RECEPTOR (alpha-SUBUNIT) MONOCLONAL ANTIBODY
- Document Type:
- Data Sheet
- Product Catalog Number:
- MAB1137
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Anti-Insulin, clone MAB1 Monoclonal Antibody
- Document Type:
- Certificate of Analysis
- Lot Number:
- 3003786
- Product Catalog Number:
- 05-1108
- Product Catalog Name:
- Anti-Insulin Antibody, clone1