Rapid Molecular Testing
Bulk harvest lot release testing (BHLRT) can be a biomanufacturing bottleneck, taking up to 65 days with the many regulatory-required analyses. While there have been innovations in biosafety testing, in vitrovirus detection has remained the same until now. The Blazar™ rapid molecular detection platform.
The Blazar™ rapid molecular platform is a viable alternative to in vitro detection assays
The Blazar™ platform provides researchers with accurate and highly sensitive viral detection in just days. Combining the breadth of detection of NGS with the speed and sensitivity of PCR, Blazar™ relies on degenerate PCR primers for coverage of more than 5000 viral variants. By amplifying multiple targets within a conserved region of the viral family genome, Blazar detects a much broader range of adventitious viruses as compared to traditional PCR methods.
- Fast – screen for viruses within days and release your batches faster
- Robust – sample directly from the bioreactor with no sample clean-up
- Broad coverage – detect viral variants using degenerate primers
- Sensitive – validated sensitivity of 10 genomic copies, even in challenging matrices
- Small sample volume – conserve precious material
- Automated – minimize handling errors
- Digital assessment and reporting – traceable and accurate
- Enables continuous manufacturing – expedite biomanufacturing timelines
The Blazar™ platform also reduces dependence on in vivo models for virus detection. By replacing the mouse, hamster, and rat antibody production (MAP, HAP and RAP) tests typically used to characterize rodent cells for biologics manufacturing, Blazar™ assays champion the 3Rs (Replacement, Reduction, and Refinement) and meets regulatory imperatives to decrease animal use.
The Blazar™ platform will enable next generation bioprocessing strategies – from process intensification, to connected processing, to fully continuous manufacturing – expediting biomanufacturing timelines thorough enhanced productivity. Used in combination with our BioContinuum™ Platform, the Blazar™ platform offers significant potential to revolutionize biologics production.
Maintain a competitive advantage by accelerating your biologics program with the Blazar™ platform for rapid molecular detection.