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AB10328 Anti-1A1 Antibody

Detect 1A1 using this Anti-1A1 Antibody validated for use in WB.

Anti-1A1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: AHH, AHRR, EC 1.14.14.1 , CP11, CYP1, CYPIA1 , P1-450, P450-P1, P450DX UniProt Number: P04798
AB10328
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10328
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-1A1 Antibody
      Alternate Names
      • Cytochrome P450 1A1
      Background InformationCYP1A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
      References
      Product Information
      FormatSerum
      PresentationRaw rabbit serum with 0.05% sodium azide.
      Applications
      ApplicationDetect 1A1 using this Anti-1A1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesSuggested dilutions:
      Western Blot: 1:5000
      Biological Information
      ImmunogenRecombinant human 1A1
      EpitopeAA 242 to 319
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
      Gene Symbol
      • AHH
      • AHRR
      • EC 1.14.14.1
      • CP11
      • CYP1
      • CYPIA1
      • P1-450
      • P450-P1
      • P450DX
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04798# Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
      SIZE: 512 amino acids; 58165 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      SIMILARITY: SwissProt: P04798# Belongs to the cytochrome P450 family.
      Molecular Weight58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10328 04053252584640

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies