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ABC85 Anti-ANGPTL2 Antibody

This Anti-ANGPTL2 antibody is validated for use in WB, IH for the detection of ANGPTL2.

Anti-ANGPTL2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANGPTL2, ARP2 UniProt Number: Q9UKU9
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ABC85
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC85
      DescriptionAnti-ANGPTL2 Antibody
      Alternate Names
      • Angiopoietin-related protein 2
      • Angiopoietin-like protein 2
      Background InformationThe protein named Angiopoietin-related protein 2 (ANGPTL2) or Angiopoietin-like protein 2 and encoded by the human gene named ANGPTL2/ARP2 is a secreted protein that is highly expressed in several tissues including the heart, spleen, stomach, colon, ovary and skeletal muscle. ANGPTL2 functions to induce endothelial cell sprouting in preparation for angiogenesis. ANGPTL2 is produced by endothelial cells and ANGPTL2 appears to function as an autocrine in helping to promote the sprouting response. ANGPTL2 also appears to use the same autocrine function in certain cancers and in particular in driving of metastasis. Recent research have demonstrated that tumor cell–derived ANGPTL2 increased in vitro motility and invasion in an autocrine/paracrine manner, conferring an aggressive metastatic tumor phenotype on the cells examined. Thus research is now focused on blocking the function of ANGPTL2 as one possible treatment for metastatic cancers. EMD-Millipore’s Anti-ANGPTL2 rabbit polyclonal antibody has been tested in western blot on mouse small intestine tissue extracts and in paraffin embedded immunohistochemistry on human heart tissue sections.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-ANGPTL2 antibody is validated for use in WB, IH for the detection of ANGPTL2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ANGPTL2 in human heart sections tissue.
      Biological Information
      ImmunogenN-Trx, C-6XHis-tagged recombinant protein corresponding to human ANGPTL2.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANGPTL2
      • ARP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~60 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in transfected HEK293 with ANGPTL2.

      Western Blotting Analysis: A 1:250 dilution of this antibody detected ANGPTL2 in 10 µg of transfected HEK293 with ANGPTL2.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC85 04055977122299