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ABT543 Anti-Claudin-4 Antibody

This Anti-Claudin-4 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Claudin-4.

Anti-Claudin-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CLDN4, CPER, CPETR1, WBSCR8 UniProt Number: O14493
ABT543
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT543
      DescriptionAnti-Claudin-4 Antibody
      Alternate Names
      • Claudin-4
      • Clostridium perfringens enterotoxin receptor
      • CPE-R
      • CPE-receptor
      • Williams-Beuren syndrome chromosomal region 8 protein
      Background InformationClaudin 4, also known as Clostridium perfringens enterotoxin receptor, or CPE-R, or CPE-receptor or Williams-Beuren syndrome chromosomal region 8 protein, and encoded by the gene CLDN4/CPER/CPETR1/WBSCR8, plays a critical role in tight junction specific obliteration of intercellular space. Claudin 4 directly interacts with several important tight junction associated proteins including ZO-1,2,3 and EPHA2 proteins, and through these interactions, Claudin 4 regulates tight junction formation. Claudin 4 is localized to cell junctions and membranes at tight junctions. Claudin 4 is expressed in most tissues particularly in intestine, liver, and pancreas. Defects in Claudin 4 may be associated with Williams Beuren syndrome genetic deletion syndrome. Claudin 4 is also over expressed in many cancers and thus is a target of anti-cancer research using C. perfringens enterotoxin.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-Claudin-4 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of Claudin-4.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis (ICC): 20 μg/mL from a representative lot detected Claudin-4 in human colon tissue.
      Biological Information
      ImmunogenClaudin-4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Claudin-4.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CLDN4
      • CPER
      • CPETR1
      • WBSCR8
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~58 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

      Western Blotting Analysis (WB): 1 μg/mL of this antibody detected Claudin-4 in human colon tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABT543 04055977174717

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies