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ABS222 Anti-DEPTOR Antibody

Anti-DEPTOR Antibody detects level of DEPTOR & has been published & validated for use in WB.

Anti-DEPTOR Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: PI3K, Akt, & mTOR Signaling Gene Symbol: DEPTOR, DEPDC6 UniProt Number: Q8TB45
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ABS222
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS222
      Replaces09-463
      DescriptionAnti-DEPTOR Antibody
      Alternate Names
      • DEP domain-containing mTOR-interacting protein
      • DEP domain-containing protein 6
      Background InformationDEPTOR (DEPDC6, DEP domain-containing protein 6) was recently identified as a novel mTOR-interacting protein whose over-expression in certain cell types represents a new mechanism for activating PI3K/Akt signaling and promoting cell survival. DEPTOR negatively regulates mTORC1 and mTORC2. It has been shown that loss of DEPTOR activates various targets that include p70S6K1, Akt, and SGK1, that leads to cell growth and survival. Little was known about DEPDC6 prior to the discovery of its interactions with mTOR, at which time it was given the new name of DEPTOR (Peterson, T.R., et al. (2009). Cell. 137(5):873-876).
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293 cell lyaste
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-DEPTOR Antibody detects level of DEPTOR & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the DEP domain-containing mTOR-interacting protein of human DEPTOR.
      EpitopeDEP domain-containing mTOR-interacting protein DEPTOR.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the DEP domain that contains mTOR-interacting protein DEPTOR.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human.
      Other homologies: Primate, Equine, Porcine, Canine, Rat, and Mouse based on 99%, 99%, 98%, 97%, and 96% homology, respectively.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DEPTOR
      • DEPDC6
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

      SUBUNIT STRUCTUREInteracts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2.
      Molecular Weight~46 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected DEPTOR in HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS222 04053252632846

      Documentation

      Anti-DEPTOR Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-DEPTOR Antibody Certificates of Analysis

      TitleLot Number
      Anti-DEPTOR - 1978005 1978005
      Anti-DEPTOR - 1996241 1996241
      Anti-DEPTOR - 2015579 2015579
      Anti-DEPTOR - 2050256 2050256
      Anti-DEPTOR - 2224497 2224497
      Anti-DEPTOR - 2491248 2491248
      Anti-DEPTOR - 2562011 2562011
      Anti-DEPTOR - 3235657 3235657
      Anti-DEPTOR - NG1942569 NG1942569
      Anti-DEPTOR - NRG1910823 NRG1910823
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      Brochure

      Title
      Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.