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MABT189 Anti-Delta3 Antibody, clone 1E7.2

This Anti-Delta3 Antibody, clone 1E7.2 is validated for use in WB, FC for the detection of Delta3.

Anti-Delta3 Antibody, clone 1E7.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: DLL3 UniProt Number: Q9NYJ7
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MABT189
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT189
      DescriptionAnti-Delta3 Antibody, clone 1E7.2
      Alternate Names
      • Delta-like protein 3
      • Drosophila Delta homolog 3
      • Delta3
      Background InformationDLL3, also known as Delta like ligand 3, is a transmembrane Delta-like protein principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation to inhibit primary neurogenesis. DLL3 is one of five DSL proteins that bind to the Notch receptor. Notch signaling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands family members are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in the DLL3 gene causes autosomal recessive spondylocostal dysostosis.
      References
      Product Information
      FormatPurified
      Control
      • Human liver tissue lysate
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Delta3 Antibody, clone 1E7.2 is validated for use in WB, FC for the detection of Delta3.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 0.1 µg from a representative lot detected Delta3 in HEK293 cells.
      Biological Information
      ImmunogenLinear peptide corresponding to human Delta3.
      Clone1E7.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
      Gene Symbol
      • DLL3
      UniProt Number
      UniProt SummaryFUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

      SUBUNIT STRUCTURE: Can bind and activate Notch-1 or another Notch receptor (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Probable.

      DOMAIN: The DSL domain is required for binding to the Notch receptor.

      PTM: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity).

      INVOLVEMENT IN DISEASE: Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1) [MIM:277300]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

      SEQUENCE SIMILARITIES: Contains 1 DSL domain.

      Contains 6 EGF-like domains.
      Molecular Weight~65 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human liver tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Delta3 on 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT189 04053252633799

      Documentation

      Anti-Delta3 Antibody, clone 1E7.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Delta3 Antibody, clone 1E7.2 Certificates of Analysis

      TitleLot Number
      Anti-Delta3, Clone 1E7.2 - 4147720 4147720
      Anti-Delta3, clone 1E7.2 3074933
      Anti-Delta3, clone 1E7.2 - 2219395 2219395
      Anti-Delta3, clone 1E7.2 - 3204238 3204238
      Anti-Delta3, clone 1E7.2 - 3249438 3249438
      Anti-Delta3, clone 1E7.2 - 3795274 3795274
      Anti-Delta3, clone 1E7.2 - NRG1935580 NRG1935580
      Anti-Delta3, clone 1E7.2 -2657486 2657486
      Anti-Delta3, clone 1E7.2 -2710200 2710200
      Anti-Delta3, clone 1E7.2 -2795668 2795668
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