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ABN473 Anti-GPR Antibody3

Detect GPR using this rabbit polyclonal antibody, Anti-GPR Antibody3 validated for use in western blotting, IHC & Immunofluorescence.

Anti-GPR Antibody3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: GPR3, ACCA UniProt Number: P46089
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ABN473
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN473
      DescriptionAnti-GPR Antibody3
      Alternate Names
      • G-protein coupled receptor 3
      • ACCA orphan receptor
      Background InformationG-protein coupled receptor 3 (GPR3) is a member of the G-protein coupled receptor 1 family that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD). GPR3 has been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.
      References
      Product Information
      FormatAffinity Purified
      Control
      • EL4 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect GPR using this rabbit polyclonal antibody, Anti-GPR Antibody3 validated for use in western blotting, IHC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected GPR3 in human spleen tissue.

      Immunofluorescence Analysis: 20 µg/mL from a representative lot detected GPR3 in human spleen cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human GPR3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • GPR3
      • ACCA
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~35 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in EL4 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected GPR3 in 15 µg of EL4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN473 04053252870507