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MABF2298-25UG Anti-IL-15 Antibody, clone 15G9

Anti-IL-15, clone 15G9, Cat. No. MABF2298, is a mouse monoclonal antibody that detects Interleukin-15 and is tested for use in Flow Cytometry and Immunohistochemistry (Paraffin).

MABF2298-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2298-25UG
      DescriptionAnti-IL-15 Antibody, clone 15G9
      Alternate Names
      • Interleukin-15
      Background InformationInterleukin-15 (UniProt: P40933; also known as IL-15) is encoded by the IL-15 gene (Gene ID: 3600) in human. IL-15 is a cytokine that is predominantly regulated post-transcriptionally at the levels of translation and intracellular trafficking. It stimulates the proliferation of T-lymphocytes and it shares many of the biological properties of IL-2, including stimulation of CTLL proliferation, and in vitro generation of alloantigen-specific cytotoxic T cells and nonantigen-specific lymphokine-activated killer cell. Stimulation by IL-15 requires its interaction with components of the IL-2 receptor, including IL2RB and probably IL2RG but not IL2RA. One of the most critical roles of IL-15 is in the development, survival and activation of natural killer cells. IL-15 is synthesized with a signal peptide (aa 1-29) and a propeptide (aa 30-48) that are subsequently cleaved off to generate the mature form (aa 49-162). Two isoforms of IL-15 have been described that are produced by alternative splicing. Isoform IL15-S48AA is an extracellular secreted form and isoform IL15-S21AA is not secreted but is stored intracellularly in the nucleus and cytoplasmic components. IL-15 is shown to be most abundant in placenta and skeletal muscle and is also detected in heart, lung, liver, and kidney. Isoform IL15-S21AA is preferentially expressed in testis and thymus.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS with 0.05% sodium azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-IL-15, clone 15G9, Cat. No. MABF2298, is a mouse monoclonal antibody that detects Interleukin-15 and is tested for use in Flow Cytometry and Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected IL-15 in one million THP-1 cells.

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
      Biological Information
      ImmunogenFull-length mature recombinant human Interleukin-15 (without the signal peptide and propeptide).
      EpitopeUnknown
      Clone15G9
      Concentration1 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone 15G9 is a mouse monoclonal antibody that detects human Interleukin-15.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL-15
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight18.09 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human tonsil tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected IL-15 in human tonsil tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at +2°C to +8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2298-25UG 04061842592210