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ABE195 Anti-JMJD1A Antibody

Anti-JMJD1A Antibody is a Rabbit Polyclonal Antibody for detection of JMJD1A also known as lysine (K)-specific demethylase 3A, testis-specific protein A
JMJD1A, JMJD1 & has been validated in WB.

Anti-JMJD1A Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: JHDM2A, TSGA, JHMD2A, JMJD1A, JMJD1, KDM3A UniProt Number: Q9Y4C1
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ABE195
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABE195
      DescriptionAnti-JMJD1A Antibody
      Alternate Names
      • JMJD
      • lysine (K)-specific demethylase 3A
      • testis-specific protein A
      • jumonji domain containing 1A
      • jumonji C domain-containing histone demethylase 2A
      • jumonji domain containing 1
      • Jumonji domain-containing protein 1A
      • JmjC domain-containing histone demethylation protein 2A
      • lysine-specific demethylase 3A
        JMJD1A
      • JMJD1
      Background InformationJMJD1A (jumonji domain-containing 1a), also known as JHDM2A is member of the jumonji (jmj) domain containing gene family of proteins. This protein functions as a histone demethylase that demethylates mono and dimethyl lysine 9 of histone H3. Consequently, this protein plays a role in the regulation of chromatin structure and influences transcriptional activation and suppression. Loss of function of JMJD1A leads to embryonic stem cell differentiation. JMJD1A has also been implicated in smooth muscle cell-specific transcription, hypoxic gene expression and tumor growth.
      References
      Product Information
      FormatSerum
      Control
      • HeLa nuclear extract
      PresentationRabbit polyclonal serum containing 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-JMJD1A Antibody is a Rabbit Polyclonal Antibody for detection of JMJD1A also known as lysine (K)-specific demethylase 3A, testis-specific protein A
      JMJD1A, JMJD1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human JMJD1A.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
      Gene Symbol
      • JHDM2A
      • TSGA
      • JHMD2A
      • JMJD1A
      • JMJD1
      • KDM3A
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

      COFACTOR: Binds 1 Fe2+ ion per subunit.

      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).

      DOMAIN: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

      Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.

      Contains 1 JmjC domain.

      SEQUENCE CAUTION: The sequence BAA34462.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
      Molecular Weight ~147 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa nuclear extract.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected JMJD1A on 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE195 04053252415333