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AB2971-25UG Anti-LAMP-1 (CD107a) (rabbit polyclonal)

This Anti-LAMP-1 (CD107a) Antibody is validated for use in WB, IC for the detection of LAMP-1 (CD107a).

Anti-LAMP-1 (CD107a) (rabbit polyclonal) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional, Tumor Markers Gene Symbol: LAMP1, LAMP-1, LAMPA, LGP120, CD107a UniProt Number: P11279
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AB2971-25UG
25 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Rhesus MacaqueWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2971-25UG
      DescriptionAnti-LAMP-1 (CD107a) (rabbit polyclonal)
      Alternate Names
      • lysosomal-associated membrane protein 1
      • lysosome-associated membrane glycoprotein 1
      • Lysosome-associated membrane protein 1
      • CD107 antigen-like family member A
      • CD107a antigen
      Background InformationLysosome-associated membrane protein 1 (LAMP-1) is a highly glycosolated, single-pass type 1 membrane protein belonging to the lysosome- associated membrane protein family; a group of proteins that make up the majority of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-1 functions to traffic carbohydrate ligands to selectins. It is also thought to play a role in tumor cell metastasis.
      References
      Product Information
      FormatAffinity Purified
      Control
      • EL4 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-LAMP-1 (CD107a) Antibody is validated for use in WB, IC for the detection of LAMP-1 (CD107a).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blot (Snap i.d.) Analysis: 1 µg/mL from a previous lot detected LAMP-1 in 10 µg of EL4 cell lysate.

      Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected LAMP-1 in NIH/3T3, A431, and HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LAMP-1 at the topological domain (Lumenal).
      EpitopeTopological domain (Lumenal)
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThe antibody recognizes LAMP-1 at the topological domain (Lumenal).
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Predicted to react with rhesus macaque based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq].
      Gene Symbol
      • LAMP1
      • LAMP-1
      • LAMPA
      • LGP120
      • CD107a
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

      PTM: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.

      SEQUENCE SIMILARITIES: Belongs to the LAMP family.
      Molecular Weight~ 95kDa observed. Although the calculated MW 45 kDa, LAMP-1 is heavily glycosylated and therefore, MW typically can be expected between 90-120 kDa. Uncharacterized bands may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in EL4 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected LAMP-1 in 10 µg of EL4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2971-25UG 04054839337369

      Documentation

      Anti-LAMP-1 (CD107a) (rabbit polyclonal) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LAMP-1 (CD107a) (rabbit polyclonal) Certificates of Analysis

      TitleLot Number
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 3693164 3693164
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 3892539 3892539
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 4069772 4069772
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) - 4137125 4137125
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody Q2909963
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody 3126005
      Anti-LAMP-1 (CD107a) (rabbit polyclonal) Polyclonal Antibody 3090198
      Anti-LAMP-1 (CD107a) - 3352431 3352431
      Anti-LAMP-1 (CD107a) - 3469480 3469480
      Anti-LAMP-1 (CD107a) - 3510219 3510219