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AB10514P Anti-Serotonin Transporter Antibody

This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.

Anti-Serotonin Transporter Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: 5-HTT , 5HTT, HTT, OCD1, SERT, hSERT UniProt Number: P31645
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AB10514P
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10514P
      ReplacesAB1594P
      DescriptionAnti-Serotonin Transporter Antibody
      Alternate Names
      • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
      • sodium-dependent serotonin transporter
      • serotonin transporter
      • Solute carrier family 6 member 4
      • Na+/Cl- dependent serotonin transporter
      • 5HT transporter
      • 5-hydroxytryptamine transporter
      Background InformationThis gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Western Blot : Human lung lysate.
      PresentationPurified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.
      EpitopeCenter region
      Concentration1 mg/ml
      HostRabbit
      SpecificityThe antibody reacts with the 70 kDa serotonin transporter protein.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteReacts with human, mouse and rat. Other species have not been tested. 100% homology to human, monkey, chimp, horse, mouse, rat, cow, sheep.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • 5-HTT
      • 5HTT
      • HTT
      • OCD1
      • SERT
      • hSERT
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.

      SUBUNIT STURCTURE: Interacts with TGFB1I1.

      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

      POLYMORPHISM: A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.

      The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].

      Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].

      MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

      SEQUENCE SIMILARITIES: Belongs to the sodium:neurotransmitter symporter (SNF) family.
      Molecular Weight70 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10514P 04053252506383

      Documentation

      Anti-Serotonin Transporter Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Serotonin Transporter Antibody Certificates of Analysis

      TitleLot Number
      Anti-Serotonin Transporter - 2397161 2397161
      Anti-Serotonin Transporter - 2436373 2436373
      Anti-Serotonin Transporter - 2234205 2234205
      Anti-Serotonin Transporter - 3012249 3012249
      Anti-Serotonin Transporter - 3321076 3321076
      Anti-Serotonin Transporter - 3487582 3487582
      Anti-Serotonin Transporter - 3755447 3755447
      Anti-Serotonin Transporter - 3938557 3938557
      Anti-Serotonin Transporter - 4044757 4044757
      Anti-Serotonin Transporter - 4139208 4139208
      Show more

      Related Products & Applications

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      Catalogue Number Description  
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      AB9726 Anti-Serotonin Transporter Antibody Show Pricing & Availability
      MAB5618 Anti-Serotonin Transporter Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies