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MABN681 Anti-TrkA Antibody, clone 6B2

Anti-TrkA Antibody, clone 6B2 is a highly specific mouse monoclonal antibody, that targets TrkA & has been tested in western blotting, IHC & ICC.

Anti-TrkA Antibody, clone 6B2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: NTRK1, MTC, TRK, TRKA UniProt Number: P04629
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MABN681
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHC, ICCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMABN681
      DescriptionAnti-TrkA Antibody, clone 6B2
      Alternate Names
      • High affinity nerve growth factor receptor
      • Neurotrophic tyrosine kinase receptor type 1
      • TRK1-transforming tyrosine kinase protein
      • Tropomyosin-related kinase A
      • Tyrosine kinase receptor
      • Tyrosine kinase receptor A
      • Trk-A
      • gp140trk
      • p140-TrkA
      Background InformationTrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.
      References
      Product Information
      FormatAscites
      Control
      • Human brain tissue lysate
      PresentationMouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TrkA Antibody, clone 6B2 is a highly specific mouse monoclonal antibody, that targets TrkA & has been tested in western blotting, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100 dilution from a representative lot detected TrkA in human brain and rat cerebellum tissues.

      Immunocytochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected TrkA in PC-12 cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified recombinant extracellular fragment of TrkA expressed in HEK293 cells.
      Clone6B2
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NTRK1
      • MTC
      • TRK
      • TRKA
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~87 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 4 isoforms ranging between ~77 kDa and ~87 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected TrkA in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN681 04053252909269

      Documentation

      Anti-TrkA Antibody, clone 6B2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TrkA Antibody, clone 6B2 Certificates of Analysis

      TitleLot Number
      Anti-TrkA, clone 6B2 -VP1811302 VP1811302
      Anti-TrkA, clone 6B2 - VP1403121 VP1403121
      Anti-TrkA, clone 6B2 - VP1405160 VP1405160
      Anti-TrkA, clone 6B2 - VP1307025 VP1307025
      Anti-TrkA, clone 6B2 - VP2106185 VP2106185
      Anti-TrkA, clone 6B2 - VP2205190 VP2205190
      Anti-TrkA, clone 6B2 - VP2301250 VP2301250
      Anti-TrkA, clone 6B2 - VP2412040 VP2412040
      Anti-TrkA, clone 6B2 - VP2502130 VP2502130
      Anti-TrkA, clone 6B2 - VP2506240 VP2506240
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies