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AB10033 Anti-UBXD1 Antibody

Anti-UBXD1 Antibody is a Rabbit Polyclonal Antibody for detection of UBXD1 also known as UBX domain containing 1 & has been validated in WB, ICC.

Anti-UBXD1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Protein Trafficking Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: UBXN6, UBXD1, UBXDC2 UniProt Number: Q9BZV1
AB10033
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10033
      DescriptionAnti-UBXD1 Antibody
      Alternate Names
      • UBX domain containing 1
      • UBX domain protein 6
      • UBX domain-containing 1
      • UBX domain-containing 2
      • UBX domain-containing protein 1
      Background InformationUBX domain-containing protein 1 is a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. UBX domain-containing protein 1 is also involved in ubiquitin-proteasome systems.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-UBXD1 Antibody is a Rabbit Polyclonal Antibody for detection of UBXD1 also known as UBX domain containing 1 & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blot (SNAP ID) Analysis:
      0.5 - 2 µg/ml of this antibody detected UBDX1 on 10 µg of human brain tissue lysate.

      Immunocytochemistry Analysis:
      1:500 dilution from a representative lot was detected in UBXD1 in HeLa, A431, and NIH/3T3 cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the entire protein of human UBXD1.
      EpitopeEntire protein
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes UBXD1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat. Homology to Rhesus monkey is 96%. Homology to Chimpanzee is 99%.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • UBXN6
      • UBXD1
      • UBXDC2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
      SUBUNIT STRUCTURE: Interacts with VCP through the PUB domain. Interacts with SYVN1, HERPUD1, MDM2 and USP7.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › centrosome. Note: Localizes at the centrosome both in interphase and during mitosis.
      TISSUE SPECIFICITY: Enhanced expression in testis.
      SEQUENCE SIMILARITIES: Contains 1 PUB (PUG) domain.
      Contains 1 UBX domain.
      Molecular Weight~ 55 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human brain tissue lysate.

      Western Blot Analysis: 0.5 µg/ml of this antibody detected UBDX1 on 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10033 04053252620829