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06-1425 Anti-phospho-TAK1 (Ser412) Antibody

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Anti-phospho-TAK1 (Ser412) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: MAP3K7, TAK1 UniProt Number: O43318
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06-1425
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1425
      DescriptionAnti-phospho-TAK1 (Ser412) Antibody
      Alternate Names
      • Mitogen-activated protein kinase kinase kinase 7
      • Transforming growth factor-beta-activated kinase 1
      • TGF-beta-activated kinase 1
      Background InformationTAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Lambda phosphatase treated and untreated Murine RAW cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.
      EpitopePhosphorylated Ser412
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes TAK1 phosphorylated at Ser412.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
      Gene Symbol
      • MAP3K7
      • TAK1
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway.

      COFACTOR: Magnesium.

      SIZE: 606 amino acids; 67196 Da

      SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L.

      PTM: Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation.

      SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight~70 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

      Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      06-1425 04053252630972

      Documentation

      Anti-phospho-TAK1 (Ser412) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-TAK1 (Ser412) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-TAK1 (Ser412) - 2216894 2216894
      Anti-phospho-TAK1 (Ser412) - 2324676 2324676
      Anti-phospho-TAK1 (Ser412) - 3185657 3185657
      Anti-phospho-TAK1 (Ser412) - 3728328 3728328
      Anti-phospho-TAK1 (Ser412) - 3772442 3772442
      Anti-phospho-TAK1 (Ser412) - 4041255 4041255
      Anti-phospho-TAK1 (Ser412) - 4179417 4179417
      Anti-phospho-TAK1 (Ser412) - NRG1881309 NRG1881309
      Anti-phospho-TAK1 (Ser412) -2611049 2611049
      Anti-phospho-TAK1 (Ser412) -2638121 2638121
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