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178220 Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem

Antipain, Hydrochloride, CAS 37682-72-7, is a peptidyl arginine aldehyde protease inhibitor of trypsin-like serine proteases, papain, and some cysteine proteases (IC50 = 300 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Trypsin-like serine proteases
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178220
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      37682-72-7C₂₇H₄₄N₁₀O₆ · HCl
      Description
      OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
      Effective concentration: 1-100 µM.
      Catalogue Number178220
      Brand Family Calbiochem®
      References
      ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Umezawa, H. 1976. Methods Enzymol. 55, 678.
      Product Information
      CAS number37682-72-7
      ATP CompetitiveN
      FormWhite or slightly yellowish solid
      Hill FormulaC₂₇H₄₄N₁₀O₆ · HCl
      Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationAntipain, Hydrochloride, CAS 37682-72-7, is a peptidyl arginine aldehyde protease inhibitor of trypsin-like serine proteases, papain, and some cysteine proteases (IC50 = 300 µM).
      Biological Information
      Primary TargetTrypsin-like serine proteases
      Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV9350800
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      178220 0

      Documentation

      Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      178220

      References

      Reference overview
      Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Umezawa, H. 1976. Methods Enzymol. 55, 678.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-September-2007 RFH
      DescriptionPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC50 ~500 ng/ml). Effective at concentrations of 1-100 µM.
      FormWhite or slightly yellowish solid
      CAS number37682-72-7
      RTECSYV9350800
      Chemical formulaC₂₇H₄₄N₁₀O₆ · HCl
      SolubilityH₂O (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Umezawa, H. 1976. Methods Enzymol. 55, 678.