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218832 Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem

The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-DNLD-CHO

Primary Target: caspase-3, caspase-7
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218832
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
775289-20-8C₂₀H₃₁N₅O₁₀

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218832-1MG
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      Description
      OverviewA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
      Catalogue Number218832
      Brand Family Calbiochem®
      SynonymsAc-DNLD-CHO
      References
      ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
      Product Information
      CAS number775289-20-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₃₁N₅O₁₀
      Chemical formulaC₂₀H₃₁N₅O₁₀
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-3, caspase-7
      Primary Target IC<sub>50</sub>3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
      PuritySingle main spot with additional trace spot by TLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218832-1MG 04055977218909

      Documentation

      Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      218832

      References

      Reference overview
      Yoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsAc-DNLD-CHO
      DescriptionA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
      Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number775289-20-8
      Chemical formulaC₂₀H₃₁N₅O₁₀
      Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
      Structure formulaStructure formula
      PuritySingle main spot with additional trace spot by TLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.