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CC1059 MMP-7, human, recombinant active form

MMP-7, human, recombinant active form MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Affects Function UniProt Number: P09237
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CC1059
10 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsEntrez Gene NumberSpeciesUni Prot Number
      FUNCNM_002423.3 Human P09237
      Description
      Catalogue NumberCC1059
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMMP-7, human, recombinant active form
      OverviewMOLECULAR WT:

      19,130 calculated from amino acid sequence and 20,000 from SDS-PAGE, followed by staining with CBB R-250.
      Alternate Names
      • Matrilysin
      References
      Product Information
      PresentationSolution in 10 mM HEPES (pH 7.4)-5 mM CaCl2-0.15 M NaCl.
      Quality LevelMQ100
      Applications
      Key Applications
      • Affects Function
      Biological Information
      Concentration0.1 mg/mL
      SourceRecombinant E. Coli; prepared from recombinant human promatrilysin
      Specific ActivitySPECIFIC ACTIVITY: <br /><br />5,000 U/mg protein <br /><br />One unit of enzyme activity is defined as the quantity required to digest 1 μg of Azocoll/min. at pH 7.5 and 37°C in the presence of 0.5 mM p-aminophenylmercuric acetate.
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
      Gene Symbol
      • MMP7
      • MPSL1
      • matrin
      • MMP-7
      • PUMP-1
      • Matrin
      • PUMP1
      • EC 3.4.24.23
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
      COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
      SIZE: 267 amino acids; 29677 Da
      DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      SIMILARITY: Belongs to the peptidase M10A family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -80ºC for up to one year.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      CC1059 04053252676147

      Documentation

      Protocols

      Title
      MMP Activation Chart

      MMP-7, human, recombinant active form SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-7, human, recombinant active form Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CD49f PHYCOERYTHRIN-CONJUGATED MONOCLONAL ANTIBODY 3087150
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3156043 3156043
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3321198 3321198
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3712516 3712516
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3767443 3767443
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3821800 3821800
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3856696 3856696
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3873579 3873579
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3915569 3915569
      RECOMBINANT HUMAN MMP-7 MATRILYSIN - 3989541 3989541
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