573097 Sigma-AldrichSTAT3 Inhibitor III, WP1066
STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.
More>> STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent. Less<<STAT3 Inhibitor III, WP1066 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 857064-38-1 | C₁₇H₁₄BrN₃O |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 573097-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo. Also available in InSolution™ format (Cat. No. 573129. |
| Catalogue Number | 573097 |
| Brand Family | Calbiochem® |
| References | |
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| References | Iwamaru, A., et al. 2007. Oncogene, 26, 2435. |
| Product Information | |
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| CAS number | 857064-38-1 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₄BrN₃O |
| Chemical formula | C₁₇H₁₄BrN₃O |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 573097-10MG | 04055977266382 |
Documentation
STAT3 Inhibitor III, WP1066 SDS
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STAT3 Inhibitor III, WP1066 Certificates of Analysis
| Title | Lot Number |
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| 573097 |
References
| Reference overview |
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| Iwamaru, A., et al. 2007. Oncogene, 26, 2435. |
Brochure
| Title |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Pathways and Biomarkers of JAK/STAT Signaling |
Technical Info
| Title |
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| JAK/STAT Signaling Research Focus |