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171588 Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem

171588
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₅H₄₆N₆O₈
      Description
      Overview

      This product has been discontinued.



      A modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood-brain barrier and acts as a β-sheet breaker. Reported to increase neuronal survival and reduce brain inflammation in a transgenic mouse model of Alzheimer’s disease, probably due to a reduction in Aβ deposits. Displays greater stability against proteolytic degradation (t1/2 > 24 hours in human plasma and cerebrospinal fluid; ~ 37 minutes in blood).

      Catalogue Number171588
      Brand Family Calbiochem®
      SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
      References
      ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₅H₄₆N₆O₈
      Chemical formulaC₃₅H₄₆N₆O₈
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetReduction in Aβ deposits
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aβ₄₂ Fibrillogenesis Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      171588

      References

      Reference overview
      Permanne, B., et al. 2002. FASEB J. 16, 860.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2008 RFH
      SynonymsAmyloid β₄₂ Fibrillogenesis Inhibitor III, iAβ5p, Ac-LPFFD-NH₂
      DescriptionA modified analog of Aβ42 Fibrillogenesis Inhibitor I (Cat. No. 171586) that crosses the blood/brain barrier and acts as a β-sheet breaker. Increases neuronal survival with a concomitant reduction in brain inflammation by inducing a dramatic reduction in Aβ deposition in a transgenic mouse model of Alzheimer's disease. Displays greater stability against proteolytic degradation (t½ > 24 h in human plasma and cerebrospinal fluid; ~37 min in blood).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₄₆N₆O₈
      Peptide SequenceAc-Leu-Pro-Phe-Phe-Asp-NH₂
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 6 months at -20°C. Stock solutions in H₂O are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesPermanne, B., et al. 2002. FASEB J. 16, 860.