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171272 AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem

171272
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Key Spec Table

Empirical FormulaCAS #
C₁₈H₂₁N₃O₃316130-82-2

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171272-10MG
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      Description
      OverviewA cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.
      Catalogue Number171272
      Brand Family Calbiochem®
      SynonymsRSVA314, AMPK Signaling Activator VI
      References
      ReferencesVingtdeux, V., et al. 2011. FASEB J. 25, 219.
      Product Information
      CAS number316130-82-2
      FormYellow solid
      Hill FormulaC₁₈H₂₁N₃O₃
      Chemical formulaC₁₈H₂₁N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      171272

      References

      Reference overview
      Vingtdeux, V., et al. 2011. FASEB J. 25, 219.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2011 RFH
      SynonymsRSVA314, AMPK Signaling Activator VI
      DescriptionA cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number316130-82-2
      Chemical formulaC₁₈H₂₁N₃O₃
      Structure formulaStructure formula
      Purity>90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVingtdeux, V., et al. 2011. FASEB J. 25, 219.