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116825 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt

A cell-permeable, metabolically-stable precursor of Rp-cAMPS that acts as a competitive inhibitor of protein kinase A type I and II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-MB-cAMPS, Na, PKA Inhibitor X

Primary Target: PKA1, PKA2
116825
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
152218-23-0C₁₄H₁₇N₅O₆PS · Na
Description
Overview

This product has been discontinued.





A cell-permeable, metabolically-stable precursor of Rp-cAMPS (Cat. No. 116814) that acts as a competitive inhibitor of protein kinase A type I and II. During metabolic activation by esterases, the inhibitor and butyrate are released. Reported to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. More lipophilic and cell-permeable than Rp-cAMPS.
Note: 5 µmol = 2.19 mg.
Catalogue Number116825
Brand Family Calbiochem®
SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
References
ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
Product Information
CAS number152218-23-0
ATP CompetitiveY
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₄H₁₇N₅O₆PS · Na
Chemical formulaC₁₄H₁₇N₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPKA1, PKA2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
116825 0

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt SDS

Title

Safety Data Sheet (SDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 2ʹ-O-Monobutyryl-, Rp-Isomer, Sodium Salt Certificates of Analysis

TitleLot Number
116825

References

Reference overview
Vischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-September-2007 RFH
SynonymsRp-MB-cAMPS, Na, PKA Inhibitor X
DescriptionA cell-permeable precursor of Rp-cAMPS (Cat. No. 116814), a PKA inhibitor. Rp-MB-cAMPS is cleaved by intracellular esterases to release butyrate and Rp-cAMPS. The Rp-cAMPS binds to the cAMP binding site on PKA type I and type II, thereby prevents holoenzyme dissociation and PKA activation. Has been shown to inhibit glucose-induced proliferation of the pancreatic β-cell line, INS-1. Note: 5 µmol = 2.19 mg.
FormLyophilized
CAS number152218-23-0
Chemical formulaC₁₄H₁₇N₅O₆PS · Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Toxicity Standard Handling
ReferencesVischer, U.M., and Wollheim, C.B. 1998. Blood 91, 118.