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164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

164640
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Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₂₆ClN₇O220792-57-4

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164640-5MG
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      Description
      OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
      Catalogue Number164640
      Brand Family Calbiochem®
      Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
      References
      ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
      Product Information
      CAS number220792-57-4
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
      FormPale yellow solid
      Hill FormulaC₁₉H₂₆ClN₇O
      Chemical formulaC₁₉H₂₆ClN₇O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
      Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aminopurvalanol A - CAS 220792-57-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      164640

      References

      Reference overview
      Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
      DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220792-57-4
      Chemical formulaC₁₉H₂₆ClN₇O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (40 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.