327768 Angiostatin, Human, Recombinant, Pichia pastoris

327768
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product.






      Recombinant, human angiostatin expressed in Pichia pastoris. Angiostatin is a proteolytic fragment of plasminogen constituting kringles 1-4. A specific inhibitor of endothelial cell proliferation and one of the most potent and specific natural inhibitors of angiogenesis and metastatic tumor growth.
      Catalogue Number327768
      Brand Family Calbiochem®
      References
      ReferencesCao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O'Reilly, M.S., et al. 1994. Cell 79, 315.
      Product Information
      CAS number86090-08-6
      DeclarationSold under license of U.S. Patents 6,521,439, 6,723,536, and corresponding patents.
      FormLiquid
      FormulationIn 0.9% NaCl.
      Applications
      Biological Information
      Biological activity10 µg/ml angiostatin will inhibit 60% tube formation in the presence of 10 ng/ml VEGF and 50% tube formation in the presence of 5 ng/ml bFGF.
      Purity≥90% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsEndotoxin: ≤ 0.50 EU/mg
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Angiostatin, Human, Recombinant, Pichia pastoris Certificates of Analysis

      TitleLot Number
      327768

      References

      Reference overview
      Cao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O'Reilly, M.S., et al. 1994. Cell 79, 315.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-October-2007 JSW
      DescriptionRecombinant, human angiostatin expressed in Pichia pastoris. Angiostatin is a proteolytic fragment of plasminogen constituting kringles 1-4. A specific inhibitor of endothelial cell proliferation and one of the most potent and specific natural inhibitors of angiogenesis and metastatic tumor growth.
      FormLiquid
      FormulationIn 0.9% NaCl.
      Concentration Label Please refer to vial label for lot-specific concentration
      CAS number86090-08-6
      Purity≥90% by HPLC
      ContaminantsEndotoxin: ≤ 0.50 EU/mg
      Biological activity10 µg/ml angiostatin will inhibit 60% tube formation in the presence of 10 ng/ml VEGF and 50% tube formation in the presence of 5 ng/ml bFGF.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesCao, Y. 1999. Haematologica 84, 643. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. Cao, Y., et al. 1996. J. Biol. Chem. 271, 29461. O'Reilly, M.S., et al. 1994. Cell 79, 315.