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204869 Anti-Complement 3 Goat pAb

204869
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Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
Bab, Gp, Ht, Eq, H, M, Rb, RGtPolyclonal Antibody

Pricing & Availability

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204869-1ML
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      Description
      OverviewMonospecific for C3 complement component. May also recognize C3 fragments, C3a, C3b, and C3c.
      Catalogue Number204869
      Brand Family Calbiochem®
      References
      ReferencesInal, J.M., et al. 2002. J. Immunol. 168, 5213.
      Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
      Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
      Product Information
      FormLiquid
      FormulationSerum diluted in 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
      Positive controlPurified C3 protein (Cat. No. 204885)
      Preservative≤0.1% sodium azide
      Quality LevelMQ100
      Applications
      Application ReferencesImmunoblotting Inal, J.M., et al. 2002. J. Immunol. 168, 5213. Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128. Flow Cytometry Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Immunocytochemistry Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
      Key Applications Immunoelectrophoresis
      Flow Cytometry
      Immunoblotting (Western Blotting)
      Immunocytochemistry
      Application NotesFlow Cytometry (see application references)
      Immunoblotting (see application references)
      Immunocytochemistry (see application references)
      Immunoelectrophoresis (use undiluted)
      Application CommentsMonospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b, and C3c. Antibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogenpurified, human C3 complement component
      ImmunogenHuman
      HostGoat
      IsotypeIgG
      Species Reactivity
      • Baboon
      • Guinea Pig
      • Hamster
      • Horse
      • Human
      • Mouse
      • Rabbit
      • Rat
      Antibody TypePolyclonal Antibody
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Complement 3 Goat pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Complement 3 Goat pAb Certificates of Analysis

      TitleLot Number
      204869

      References

      Reference overview
      Inal, J.M., et al. 2002. J. Immunol. 168, 5213.
      Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
      Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.

      Citations

      Title
    • Jameel M. Inal and Jurg A. Schifferli. (2002) Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C21. Journal of Immunology 168, 5213-5221.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2007 RFH
      ApplicationFlow Cytometry (see application references)
      Immunoblotting (see application references)
      Immunocytochemistry (see application references)
      Immunoelectrophoresis (use undiluted)
      DescriptionGoat polyclonal antibody supplied as defibrinated, delipidized, and adsorbed (as needed) serum. Recognizes the C3 complement component.
      BackgroundThe complement system provides innate defense against microbial infection and is a "complement" to antibody mediated immunity. The complement system consists of thirty five interacting plasma and membrane associated proteins which contribute to host-defense and initiate and amplify inflammation, even in the preimmune state where specific antibodies and lymphocytes are not available. In addition to the complement components themselves, this system also contains several soluble factors that prevent spontaneous complement activation from occurring in solution, as well as, several regulatory membrane associated proteins that protect host cells from accidental complement attack. Cleavage of the C3 component by either the classical pathway or the alternative pathway releases C3a and C3b. C3a appears to be important in many inflammatory responses while the C3b fragment covalently binds to the cell or bacterial surface and plays a role in opsonisation. Binding of C3b to the C4b component of the C3 convertase, results in C5 convertase (C4b3b2a) formation.
      HostGoat
      Immunogen speciesHuman
      Immunogenpurified, human C3 complement component
      IsotypeIgG
      Speciesbaboon, not bovine, not canine, not chicken, not feline, guinea pig, hamster, horse, human, mouse, rabbit, rat, not sheep
      Positive controlPurified C3 protein (Cat. No. 204885)
      FormLiquid
      FormulationSerum diluted in 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      Preservative≤0.1% sodium azide
      CommentsMonospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b, and C3c. Antibody should be titrated for optimal results in individual systems.
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesInal, J.M., et al. 2002. J. Immunol. 168, 5213.
      Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
      Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
      Citation
    • Jameel M. Inal and Jurg A. Schifferli. (2002) Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C21. Journal of Immunology 168, 5213-5221.
    • Application referencesImmunoblotting Inal, J.M., et al. 2002. J. Immunol. 168, 5213. Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128. Flow Cytometry Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Immunocytochemistry Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.