428033 Anti-Cu2+-Oxidized Low Density Lipoprotein Rabbit pAb

428033
  
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      Overview

      Replacement Information

      Key Spec Table

      Host
      Rb
      Description
      Overview

      This product has been discontinued.





      Recognizes both fully oxidized modifications of LDL and minimally oxidized LDL, but the reaction to native LDL is weak. Does not react with other oxidized proteins.
      Catalogue Number428033
      Brand Family Calbiochem®
      References
      ReferencesHerrick, A.L., et al. 2001. Rheumatology 40, 401.
      Lau, B.H. 2001. J. Nutrition 131, 985s.
      Product Information
      FormLyophilized
      FormulationUndiluted serum.
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Immunohistochemistry
      Application NotesELISA (1:500-1:5000)
      Immunohistochemistry (1:500)
      Application CommentsDoes not react with other oxidized proteins. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogenfully Cu2+-oxidized human low density lipoprotein (LDL)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsReconstitute with 100 µl dH₂O. Following reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cu2+-Oxidized Low Density Lipoprotein Rabbit pAb Certificates of Analysis

      TitleLot Number
      428033

      References

      Reference overview
      Herrick, A.L., et al. 2001. Rheumatology 40, 401.
      Lau, B.H. 2001. J. Nutrition 131, 985s.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-August-2008 JSW
      ApplicationELISA (1:500-1:5000)
      Immunohistochemistry (1:500)
      DescriptionRabbit polyclonal antibody supplied as lyophilized, undiluted serum. Recognizes both fully oxidized modifications of LDL and minimally oxidized LDL, but the reaction to native LDL is weak.
      BackgroundOxidation of LDL plays an important role in the initiation and progression of atherosclerosis. Arterial macrophages take up oxidized low-density lipoproteins (OxLDL), leading to cellular accumulation of cholesterol and oxysterols. OxLDL, but not native LDL, promotes vascular dysfunction by exerting direct cytotoxicity toward endothelial cells, by increasing chemotactic properties for monocytes, by transforming macrophages to foam cells via scavenger-receptors and by enhancing the proliferation of various cell types, e.g., endothelial cells, monocytes and smooth muscle cells; all of these events are recognized as contributing to atherogenesis.
      HostRabbit
      Immunogen speciesHuman
      Immunogenfully Cu2+-oxidized human low density lipoprotein (LDL)
      IsotypeIgG
      Speciesa broad range of species
      FormLyophilized
      FormulationUndiluted serum.
      CommentsDoes not react with other oxidized proteins. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsReconstitute with 100 µl dH₂O. Following reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesHerrick, A.L., et al. 2001. Rheumatology 40, 401.
      Lau, B.H. 2001. J. Nutrition 131, 985s.