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178197 Antimycin A

178197
  
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      This product has been discontinued.



      A cell-permeable compound (70 µM) that is shown to increase the percentage of Calu-6 cells, which display a loss in MMP (ΔΨm) by ~ 33%, the percentage of cells arrested in the sub-G1 phase by ~ 14%, the percentage of GSH-depleted cells by ~ 21%, the mean superoxide anion radical levels by ~ 175%, and inhibit the growth the same cultures by up to ~ 80% over controls. In general, co-treatment with a p38-, JNK-, or MEK-MAPK inhibitor is demonstrated to magnify the effects of compound alone in Calu-6 cultures, with some exceptions. (Please refer to our complete listing of MAPK Inhibitors). In patch clamp studies, 2 µM of Antimycin A (AMA) is shown to inhibit the activities of the 10 pS channel and the MCC of the inner mitochondrial membrane, but promotes the opening of both channels at much higher concentrations in a reversible manner. Also is found to inhibit the growth of A549 cells via inducing cell cycle arrest and maintain the pluripotency of hESCs at concentrations of 2-100 µM and 20 nM, respectively. This compound is known to inhibit succinate oxidase, NADH oxidase, and mitochondrial electron transport chain between cytochrome b and c.

      Catalogue Number178197
      Brand Family Calbiochem®
      References
      ReferencesHan, Y.H., et al. 2010. Mol. Cell. Biochem. 333, 211; Varum, S., et al. 2009. Stem Cell Res. 3, 142; Han, Y., et al. 2008. Oncol. Rep. 20, 689; Campo, H.L., et al. 1992. J. Biol. Chem. 12, 8123;
      Product Information
      FormOff-white solid
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
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      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
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      References

      Reference overview
      Han, Y.H., et al. 2010. Mol. Cell. Biochem. 333, 211; Varum, S., et al. 2009. Stem Cell Res. 3, 142; Han, Y., et al. 2008. Oncol. Rep. 20, 689; Campo, H.L., et al. 1992. J. Biol. Chem. 12, 8123;

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