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181305 Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem

This compound was originally isolated from the marine ascidian Eudistoma sp.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CDK4/D1
181305
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118458-54-1C₂₀H₁₁N₃O₂
Description
Overview

This product has been discontinued.





This compound was originally isolated from the marine ascidian Eudistoma sp. Displays potent inhibitory activity against CDK4/D1 (IC50 = 59 nM). Also acts as a potent inhibitor of human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200 nM).
Catalogue Number181305
Brand Family Calbiochem®
References
ReferencesZhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
Horton, P.A., et al. 1994. Experientia 50, 843.
Product Information
CAS number118458-54-1
ATP CompetitiveN
FormRed solid
Hill FormulaC₂₀H₁₁N₃O₂
Chemical formulaC₂₀H₁₁N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetCDK4/D1
Primary Target IC<sub>50</sub>59 nM against CDK4/D1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
181305 0

Documentation

Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem Certificates of Analysis

TitleLot Number
181305

References

Reference overview
Zhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
Horton, P.A., et al. 1994. Experientia 50, 843.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
DescriptionA synthetic version of the natural compound originally isolated from the marine ascidian Eudistoma sp. Displays potent inhibitory activity against CDK4/cyclin D1 (IC50 = 59 nM). Also reported to inhibit human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200 nM).
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number118458-54-1
Chemical formulaC₂₀H₁₁N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
Horton, P.A., et al. 1994. Experientia 50, 843.