217504 Cardiotoxin, Naja nigricollis

217504
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      We are offering Cardiotoxin, Naja pallida (Cat. No. 217503) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






      A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by the sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
      Catalogue Number217504
      Brand Family Calbiochem®
      References
      ReferencesJang, J.Y., et al. 1997. Biochemistry 36, 4635.
      Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
      Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
      Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.
      Product Information
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormLyophilized solid
      Hill FormulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
      Chemical formulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
      ReversibleN
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>1.8 µM against protein kinase C
      Purity≥95% by IEF
      Physicochemical Information
      Cell permeableN
      Contaminantsphospholipase A₂ activity: <2%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSFH7482450
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cardiotoxin, Naja nigricollis Certificates of Analysis

      TitleLot Number
      217504

      References

      Reference overview
      Jang, J.Y., et al. 1997. Biochemistry 36, 4635.
      Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
      Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
      Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-June-2010 RFH
      DescriptionA cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
      FormLyophilized solid
      RTECSFH7482450
      Chemical formulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
      Purity≥95% by IEF
      Contaminantsphospholipase A₂ activity: <2%
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1835
      ReferencesJang, J.Y., et al. 1997. Biochemistry 36, 4635.
      Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
      Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
      Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.