218699 Casein Kinase II Inhibitor II, DMAT

218699
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We are offering Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable brominated benzimidazolo compound that acts as a potent, high affinity and ATP-competitive inhibitor of CK2 (IC50 = 140 nM for rat liver CK2; Ki = 40 nM). Displays ~1300 fold greater selectivity over CK1 (IC50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No. 218697). Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1a) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Shown to induce apoptosis in Jurkat T cells at 2.5 µM. A 10 mM (5 mg/1.05 ml) solution of Casein Kinase II Inhibitor, DMAT (Cat. No. 218706), in DMSO is also avialable.
      Catalogue Number218699
      Brand Family Calbiochem®
      Synonyms2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, CK2 Inhibitor II, DMAT
      References
      ReferencesPagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.
      Product Information
      CAS number749234-11-5
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₉H₇Br₄N₃
      Chemical formulaC₉H₇Br₄N₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCK2
      Primary Target IC<sub>50</sub>140 nM
      Secondary targetCK2 Ki = 40 nM, CK1 (IC₅₀ > 200 µM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stcok solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase II Inhibitor II, DMAT SDS

      Title

      Safety Data Sheet (SDS) 

      Casein Kinase II Inhibitor II, DMAT Certificates of Analysis

      TitleLot Number
      218699

      References

      Reference overview
      Pagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 JSW
      Synonyms2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, CK2 Inhibitor II, DMAT
      DescriptionA cell-permeable brominated benzimidazolo compound that acts as a potent, high affinity and ATP-competitive inhibitor of CK2 (IC50 = 140 nM for rat liver CK2; Ki = 40 nM). Displays ~1,300 fold greater selectivity over CK1 (IC50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No. 218697). Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1a) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Shown to induce apoptosis in Jurkat T cells at 2.5 µM.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number749234-11-5
      Chemical formulaC₉H₇Br₄N₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stcok solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040.