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218747 Caspase-3 Inhibitor II, Biotin Conjugate

218747
  
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      Overview

      Replacement Information
      Description
      OverviewBiotinylated derivative of Caspase-3 inhibitor II (Cat. No. 264155) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will enhance inhibitory activity in cell-free systems.
      Catalogue Number218747
      Brand Family Calbiochem®
      SynonymsBiotin-X-DEVD-FMK
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.
      Product Information
      FormBrown solid
      Hill FormulaC₃₈H₅₉FN₇O₁₃S
      Chemical formulaC₃₈H₅₉FN₇O₁₃S
      ReversibleN
      Applications
      Biological Information
      Primary Targetcaspase-6, caspase-7
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceBiotin-X-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CH₂F* (X = linker)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-3 Inhibitor II, Biotin Conjugate Certificates of Analysis

      TitleLot Number
      218747

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2008 JSW
      SynonymsBiotin-X-DEVD-FMK
      DescriptionBiotinylated derivative of Caspase-3 Inhibitor II (Cat. No. 264155) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will increase inhibitory activity in cell-free systems.
      FormBrown solid
      Chemical formulaC₃₈H₅₉FN₇O₁₃S
      Peptide SequenceBiotin-X-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CH₂F* (X = linker)
      Purity≥95% by TLC
      SolubilityDMSO (17.5 mg/ml)
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.