218754 Caspase-5 Substrate II, Fluorogenic

218754
  
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      Overview

      Replacement Information

      Key Spec Table

      Description
      Overview

      This product has been discontinued.





      A fluorogenic substrate for caspase-5 (ICErel-III, TY), caspase-1, and caspase-4. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
      Catalogue Number218754
      Brand Family Calbiochem®
      SynonymsAc-WEHD-AFC
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
      Product Information
      ATP CompetitiveN
      FormYellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₈H₃₇F₃N₈O₁₁
      Chemical formulaC₃₈H₃₇F₃N₈O₁₁
      ReversibleN
      Applications
      Biological Information
      Primary TargetA fluorogenic substrate for caspase-5 (ICErel-III, TY), caspase-1, and caspase-4
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Trp-Glu-His-Asp-AFC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-5 Substrate II, Fluorogenic Certificates of Analysis

      TitleLot Number
      218754

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      SynonymsAc-WEHD-AFC
      DescriptionA fluorogenic substrate for caspase-5 (ICErel-III, TY), caspase-1, and caspase-4. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
      FormYellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₃₈H₃₇F₃N₈O₁₁
      Peptide SequenceAc-Trp-Glu-His-Asp-AFC
      Purity≥95% by HPLC
      SolubilityDMSO (50 mM)
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.