218782 Caspase Substrate Set II, Fluorogenic

218782
  
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      Overview

      Replacement Information
      Description
      OverviewContains 1 mg each of Caspase-1 Substrate III, Ac-YVAD-AMC (Cat. No. 400020); Caspase-2 Substrate I, Z-VDVAD-AFC (Cat. No. 218740); Caspase-3 Substrate II, Ac-DEVD-AMC (Cat. No. 235425); Caspase-4 Substrate II, Ac-LEVD-AFC (Cat. No. 218748); Caspase-5 Substrate II, Ac-WEHD-AFC (Cat. No. 218754); Granzyme B Substrate II, Z-IETD-AFC (Cat. No. 268059); Caspase-9 Substrate I, Ac-LEHD-AFC (Cat. No. 218765); 5 mg of Caspase-6 Substrate I, Ac-VEID-AMC (Cat. No. 218760); 10 mg of AMC Reference Standard (Cat. No. 164545); and 50 mg of AFC Reference Standard (Cat. No. 164580). Supplied with a data sheet.
      Catalogue Number218782
      Brand Family Calbiochem®
      References
      ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907. Nicholson, D.W., et al. 1995. Nature 376, 37. Thornberry, N.A., et al. 1992. Nature 356, 768. Zimmerman, M., et al. 1977. Anal. Biochem. 78, 47.
      Product Information
      FormSolid
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907. Nicholson, D.W., et al. 1995. Nature 376, 37. Thornberry, N.A., et al. 1992. Nature 356, 768. Zimmerman, M., et al. 1977. Anal. Biochem. 78, 47.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2008 JSW
      DescriptionApoptosis is a normal process in development and morphogenesis. However, improperly regulated apoptosis can contribute to several pathological conditions including cancer, Alzheimer's disease, spinal muscular atrophy, ischemic cardiac damage, and autoimmune syndromes. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the catalysis of preexisting intracellular caspase proenzymes into activated caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position. The P4 residue is important in substrate recognition and specificity. For example, caspase-1 prefers a hydrophobic tyrosine residue in the P4 position, but caspase-3 prefers an anionic aspartic residue. Caspase activity can be assayed using a fluorophore (AFC or AMC). Liberation of the fluorophore from the substrate is monitored to determine caspase activity. Supplied with a data sheet.
      FormSolid
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907. Nicholson, D.W., et al. 1995. Nature 376, 37. Thornberry, N.A., et al. 1992. Nature 356, 768. Zimmerman, M., et al. 1977. Anal. Biochem. 78, 47.