219396 Cathepsin D, Bovine Spleen

219396
  
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      Overview

      Replacement Information

      Key Spec Table

      Description
      Overview

      This product has been discontinued.





      Native cathepsin D from bovine spleen. Cathepsin D is a major lysosomal aspartyl proteinase widely distributed in many cell types. It exists in two forms, a single polypeptide chain of 46 kDa, and a two-polypeptide chain form consisting of an H-chain of 34 kDa and an L-chain of 12 kDa.v
      Catalogue Number219396
      Brand Family Calbiochem®
      References
      ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
      Fortgens, P.H., et al. 1997. Immunopharmacology 36, 305.
      Takahashi, T., and Tang, J. 1981. Methods Enzymol. 80 (Pt. C), 565.
      Product Information
      CAS number9025-26-7
      Unit of DefinitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 30 minutes, at 37°C, pH 3.3, releasing peptides soluble in TCA, as measured by an increase in absorbance of 0.5 at 280 nm.
      EC number3.4.23.5
      FormLyophilized
      FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      Specific Activity≥400 units/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin D, Bovine Spleen SDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin D, Bovine Spleen Certificates of Analysis

      TitleLot Number
      219396

      References

      Reference overview
      Berchem, G., et al. 2002. Oncogene 21, 5951.
      Fortgens, P.H., et al. 1997. Immunopharmacology 36, 305.
      Takahashi, T., and Tang, J. 1981. Methods Enzymol. 80 (Pt. C), 565.

      Brochure

      Title
      Cathepsins and Related Products Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-December-2010 JSW
      DescriptionNative cathepsin D from bovine spleen. Cathepsin D is a major lysosomal aspartyl proteinase distributed in a wide variety of cells. Overexpression and alteration in secretion of cathepsin D are linked to tumor invasion and inflammation. The enzyme exists in two forms, a single chain form of 46 kDa, and a two polypeptide chain form with an H chain of 34 kDa and an L chain of 12 kDa.
      FormLyophilized
      FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
      CAS number9025-26-7
      EC number3.4.23.5
      Purity≥95% by SDS-PAGE
      Specific activity≥400 units/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 30 minutes, at 37°C, pH 3.3, releasing peptides soluble in TCA, as measured by an increase in absorbance of 0.5 at 280 nm.
      SolubilityH₂O or 2 mM Sodium Phosphate Buffer, pH 6.5. Please see vial label for lot-specific reconstitution volume.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
      Fortgens, P.H., et al. 1997. Immunopharmacology 36, 305.
      Takahashi, T., and Tang, J. 1981. Methods Enzymol. 80 (Pt. C), 565.