233230 Clotrimazole

233230
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₂H₁₇ClN₂23593-75-1
      Description
      Overview

      This product has been discontinued.





      An antifungal agent that acts as a potent and specific inhibitor of the Ca2+-activated K+ channel (Gardos channel; IC50 = 650 nM). Prevents K+ loss and dehydration of sickled erythrocytes.
      Catalogue Number233230
      Brand Family Calbiochem®
      SynonymsCLT, 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
      References
      ReferencesBrugnara, C., et al. 1995. J. Pharmacol. Exp. Ther. 273, 266.
      Rifai, N., et al. 1995. Clin. Chem. 41, 387.
      De Franceschi, L., et al. 1994. J. Clin. Invest. 93, 1670.
      Product Information
      CAS number23593-75-1
      FormOff-white solid
      Hill FormulaC₂₂H₁₇ClN₂
      Chemical formulaC₂₂H₁₇ClN₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNI4377000
      Safety Information
      R PhraseR: 22-36/38

      Harmful if swallowed.
      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Clotrimazole SDS

      Title

      Safety Data Sheet (SDS) 

      Clotrimazole Certificates of Analysis

      TitleLot Number
      233230

      References

      Reference overview
      Brugnara, C., et al. 1995. J. Pharmacol. Exp. Ther. 273, 266.
      Rifai, N., et al. 1995. Clin. Chem. 41, 387.
      De Franceschi, L., et al. 1994. J. Clin. Invest. 93, 1670.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      SynonymsCLT, 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
      DescriptionPotent, specific inhibitor of the Ca2+-activated K+ channel (Gardos channel). Prevents K+ loss and dehydration of sickled erythrocytes. Antifungal agent.
      FormOff-white solid
      CAS number23593-75-1
      RTECSNI4377000
      Chemical formulaC₂₂H₁₇ClN₂
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO and Methanol (100 µM)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Harmful
      Merck USA index14, 2417
      ReferencesBrugnara, C., et al. 1995. J. Pharmacol. Exp. Ther. 273, 266.
      Rifai, N., et al. 1995. Clin. Chem. 41, 387.
      De Franceschi, L., et al. 1994. J. Clin. Invest. 93, 1670.