317200 DMBI

317200
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₆N₂O5812-07-7
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, ATP-competitive, and potent inhibitor of the tyrosine kinase activities of the PDGF β-receptor (β-PDGFR; IC50 = 4 µM in PAC-1 cells) and FGFR1 (IC50 = 5 µM for inhibition of tyrosine phosphorylation of p90). Does not inhibit EGFR or c-Src tyrosine kinases, even at concentrations greater than 100 µM.
      Catalogue Number317200
      Brand Family Calbiochem®
      Synonyms(Z)-3-[4-(Dimethylamino)benzylidenyl]indolin-2-one, SU 4312, PDGFR Tyrosine Kinase Inhibitor XIV
      References
      ReferencesKendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
      Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Product Information
      CAS number5812-07-7
      ATP CompetitiveY
      FormOrange-red solid
      Hill FormulaC₁₇H₁₆N₂O
      Chemical formulaC₁₇H₁₆N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetB-PDGFR
      Primary Target IC<sub>50</sub>4 µM against β-PDGFR in PAC-1 cells
      Purity≥95% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      DMBI SDS

      Title

      Safety Data Sheet (SDS) 

      DMBI Certificates of Analysis

      TitleLot Number
      317200

      References

      Reference overview
      Kendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
      Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms(Z)-3-[4-(Dimethylamino)benzylidenyl]indolin-2-one, SU 4312, PDGFR Tyrosine Kinase Inhibitor XIV
      DescriptionA cell-permeable, reversible, ATP-competitive, and potent inhibitor of the tyrosine kinase activity of the PDGF β-receptor (β-PDGFR; IC50 = 4 µM in PAC-1 cells). Also inhibits FGFR1 tyrosine kinase activity (IC50 = 5 µM for inhibition of tyrosine phosphorylation of p90). Does not inhibit EGFR or c-Src tyrosine kinases, even at concentrations greater than 100 µM.
      FormOrange-red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5812-07-7
      Chemical formulaC₁₇H₁₆N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC (sum of two isomers)
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
      Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
      Sun, L., et al. 1998. J. Med. Chem. 41, 2588.