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324510 EF24 - Calbiochem

324510
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₉H₁₅F₂NO
      Description
      Overview

      This product has been discontinued.



      A cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 µM) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 µM) and NF-κB nuclear translocation (IC50 = 1.3 µM), as well as in its anticancer activity (IC50 ranges from 0.44 to 2.07 µM) in vitro. Reported to completely stop the expansion of HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.

      Catalogue Number324510
      Brand Family Calbiochem®
      Synonyms3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV
      References
      ReferencesSubramaniam, D., et al. 2008. Cancer Res. 68, 1962.
      Product Information
      FormYellow solid
      Hill FormulaC₁₉H₁₅F₂NO
      Chemical formulaC₁₉H₁₅F₂NO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. When stored at room temperature in DMSO, 2.5% decomposition per day is expected.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      EF24 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      EF24 - Calbiochem Certificates of Analysis

      TitleLot Number
      324510

      References

      Reference overview
      Subramaniam, D., et al. 2008. Cancer Res. 68, 1962.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2012 JSW
      Synonyms3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV
      DescriptionA cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 vs. 20 µM, respectively) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 vs. >50 µM, respectively) and NF-κB nuclear translocation (IC50 = 1.3 vs. 13 µM, respectively) in A549 cultures, as well as in its anticancer activity (EC50 ranges from 0.44 to 2.07 µM against various cancer cell lines). Reported to completely stop the continued volume expansion of 1-week-old HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₁₅F₂NO
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (15 mg/ml) or Ethanol (4 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. When stored at room temperature in DMSO, 2.5% decomposition per day is expected.
      Toxicity Regulatory Review
      ReferencesSubramaniam, D., et al. 2008. Cancer Res. 68, 1962.