Key Spec Table
This product has been discontinued.
A cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 µM) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 µM) and NF-κB nuclear translocation (IC50 = 1.3 µM), as well as in its anticancer activity (IC50 ranges from 0.44 to 2.07 µM) in vitro. Reported to completely stop the expansion of HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.
|Synonyms||3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV|
|References||Subramaniam, D., et al. 2008. Cancer Res. 68, 1962.|
|Structure formula Image|
|Purity||≥97% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
EF24 - Calbiochem SDS
|Subramaniam, D., et al. 2008. Cancer Res. 68, 1962.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.