362331 GAG Agonist, Adhesamine - Calbiochem

362331
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₈H₃₂Cl₂F₆N₈O₆S₂
      Description
      Overview

      This product has been discontinued.



      A symmetrical nonpeptidyl cationic diaryldispirotripiperazine compound that binds GAGs (glycosaminoglycans) in a reversible manner (KD = 0.39, 4.67, and 5.85 µM for heparin, heparan sulfate, and keratin sulfate, respectively) and effectively promotes adhesion (by ~100 and 600% at 60 µM, respectively) and growth (by ~80 and 50% in 72 h at 1 µM, respectively) of HepG2 and Jurkat cells in a dose-dependent manner. Binding studies using heparin-derived oligosaccharides indicate that the major mode of interaction involves the binding of a hexasaccharide unit by two adhesamine molecules (KD = 0.12 µM). Primary murine hippocampal neurons cultured in the presence of adhesamine are reported to exhibit earlier differentiation as well as improved survival rate when compared with neurons cultured on poly-L-lysine-coated surface. A GAGs binding antagonist Surfen is also available under Cat. No. 362330.

      Catalogue Number362331
      Brand Family Calbiochem®
      SynonymsGlycosaminoglycans Agonist
      References
      ReferencesHoshino, M., et al. 2010. Biochem. J. 427, 297.
      Yamazoe, S., et al. 2009. Chem. Biol. 16, 773.
      Product Information
      FormLight yellow solid
      Hill FormulaC₂₈H₃₂Cl₂F₆N₈O₆S₂
      Chemical formulaC₂₈H₃₂Cl₂F₆N₈O₆S₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥80% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GAG Agonist, Adhesamine - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GAG Agonist, Adhesamine - Calbiochem Certificates of Analysis

      TitleLot Number
      362331

      References

      Reference overview
      Hoshino, M., et al. 2010. Biochem. J. 427, 297.
      Yamazoe, S., et al. 2009. Chem. Biol. 16, 773.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-July-2011 RFH
      SynonymsGlycosaminoglycans Agonist
      DescriptionA symmetrical nonpeptidyl cationic diaryldispirotripiperazine compound that binds GAGs (glycosaminoglycans) in a reversible manner (KD = 0.39, 4.67, and 5.85 µM for heparin, heparan sulfate, and keratin sulfate, respectively) and effectively promotes adhesion (by ~100 and 600% at 60 µM, respectively) and growth (by ~80 and 50% in 72 h at 1 µM, respectively) of HepG2 and Jurkat cells in a dose-dependent manner. Binding studies using heparin-derived oligosaccharides indicate that the major mode of interaction involves the binding of a hexasaccharide unit by two adhesamine molecules (KD = 0.12 µM). Primary murine hippocampal neurons cultured in the presence of adhesamine are reported to exhibit earlier differentiation as well as improved survival rate when compared with neurons cultured on poly-L-lysine-coated surface. A GAGs binding antagonist Surfen is also available under Cat. No. 362330.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₃₂Cl₂F₆N₈O₆S₂
      Structure formulaStructure formula
      Purity≥80% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHoshino, M., et al. 2010. Biochem. J. 427, 297.
      Yamazoe, S., et al. 2009. Chem. Biol. 16, 773.