345872 Glial Derived Neurotrophic Factor, Human, Recombinant, E. coli

345872
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥97% by SDS-PAGE
      Description
      OverviewRecombinant, human glial derived neutotrophic factor expressed in E. coli. A heterogeneously glycosylated growth promoting factor that enhances neuronal survival of dopaminergic midbrain neurons. Activates receptor tyrosine kinase Ret and promotes kidney morphogenesis. Also an activator of MAP kinase. Its biological activity is destroyed by reduction of disulfide bonds.
      Catalogue Number345872
      Brand Family Calbiochem®
      SynonymsrhGDNF
      References
      ReferencesVega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
      Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
      Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
      Lev-Fen, H., et al. 1993. Science 260, 1130.
      Product Information
      FormLyophilized
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityfully biologically active when compared to native GDNF by dose-dependent ³H-dopamine uptake assay
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Glial Derived Neurotrophic Factor, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Glial Derived Neurotrophic Factor, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      345872

      References

      Reference overview
      Vega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
      Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
      Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
      Lev-Fen, H., et al. 1993. Science 260, 1130.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-June-2008 RFH
      SynonymsrhGDNF
      DescriptionRecombinant, human glial derived neutotrophic factor expressed in E. coli. Growth promoting factor that enhances neuronal survival of dopaminergic midbrain neurons. A heterogeneously glycosylated basic protein. Its biological activity is destroyed by the reduction of disulfide bonds.
      FormLyophilized
      Purity≥97% by SDS-PAGE
      Biological activityfully biologically active when compared to native GDNF by dose-dependent ³H-dopamine uptake assay
      SolubilityH₂O and most aqueous buffers. The recommended stock solution is 1 µg/100µl. For more dilute samples, add a stabilizing protein such as 0.1% BSA.
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesVega, Q.C., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 10657.
      Worby, C.A., et al. 1996. J. Biol. Chem. 271, 23619.
      Lin, L.F., et al. 1994. J. Neurochem. 63, 758.
      Lev-Fen, H., et al. 1993. Science 260, 1130.