400140 Humanin, Human, Synthetic

400140
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₁₉H₂₀₄N₃₄O₃₂S₂330936-69-1
      Description
      Overview

      This product has been discontinued.





      A 24-residue anti-apoptotic peptide that, when expressed intracellularly, offers protection against neuronal apoptosis induced by presenilin and APP (amyloid precursor protein) mutants associated with familial Alzheimer′s disease (AD). Shown to reduce cytochrome c release in vitro by directly binding to Bax (Bcl-2-associated X protein; Kd ~ 2 nM) and preventing its association with isolated mitochondria.
      Catalogue Number400140
      Brand Family Calbiochem®
      SynonymsHN, H-MAPRGFSCLLLLTSEIDLPVKRRA-OH
      References
      ReferencesGuo, B., et al. 2003. Nature. 423, 456.
      Hashimoto, Y., et al. 2003. J. Neurochem. 84, 864.
      Hashimoto, Y., et al. 2001. J. Neurosci. 21, 9235.
      Hashimoto, Y., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 6336.
      Product Information
      CAS number330936-69-1
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₁₉H₂₀₄N₃₄O₃₂S₂
      Chemical formulaC₁₁₉H₂₀₄N₃₄O₃₂S₂
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH₂N-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Humanin, Human, Synthetic Certificates of Analysis

      TitleLot Number
      400140

      References

      Reference overview
      Guo, B., et al. 2003. Nature. 423, 456.
      Hashimoto, Y., et al. 2003. J. Neurochem. 84, 864.
      Hashimoto, Y., et al. 2001. J. Neurosci. 21, 9235.
      Hashimoto, Y., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 6336.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsHN, H-MAPRGFSCLLLLTSEIDLPVKRRA-OH
      DescriptionA 24-amino acid, anti-apoptotic peptide that, when expressed intracellularly, offers protection against neuronal apoptosis induced by presenilin and amyloid precursor protein (APP) mutants associated with familial Alzheimer's disease. Shown to reduce cytochrome c release in vitro by directly binding to Bcl-2-associated X protein (Bax) (Kd ~2 nM) and preventing its association with isolated mitochondria.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number330936-69-1
      Chemical formulaC₁₁₉H₂₀₄N₃₄O₃₂S₂
      Peptide SequenceH₂N-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or 5% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGuo, B., et al. 2003. Nature. 423, 456.
      Hashimoto, Y., et al. 2003. J. Neurochem. 84, 864.
      Hashimoto, Y., et al. 2001. J. Neurosci. 21, 9235.
      Hashimoto, Y., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 6336.