401489 IKK Inhibitor X - CAS 431898-65-6 - Calbiochem

401489
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇H₁₁ClN₄O431898-65-6
      Description
      Overview

      This product has been discontinued.



      A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 = 88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).

      Catalogue Number401489
      Brand Family Calbiochem®
      SynonymsN-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide, PS-1145
      References
      ReferencesCatley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
      Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
      Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
      Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.
      Product Information
      CAS number431898-65-6
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₁ClN₄O
      Chemical formulaC₁₇H₁₁ClN₄O
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetIKK
      Primary Target IC<sub>50</sub>88 nM against IKK
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IKK Inhibitor X - CAS 431898-65-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IKK Inhibitor X - CAS 431898-65-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      401489

      References

      Reference overview
      Catley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
      Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
      Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
      Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN-(6-Chloro-9H-β-carbolin-8-yl)nicotinamide, PS-1145
      DescriptionA cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 =88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml p.o.).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number431898-65-6
      Chemical formulaC₁₇H₁₁ClN₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCatley, M.C., et al. 2006. Mol. Pharmacol. 70, 697.
      Wen, D., et al. 2006. J. Pharm. Exp. Ther. 317, 989.
      Castro, A.C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2419.
      Hideshima, T., et al. 2002. J. Biol. Chem. 277, 16639.