G0500
D-(+)-Galactosamine hydrochloride
≥99% (HPLC)
Sinónimos:
2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
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Servicio técnico
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Permítanos ayudarleQuality Segment
assay
≥99% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
≤0.5% Glucosamine (HPAE)
color
white to off-white
mp
172-180 °C
solubility
H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
storage temp.
room temp
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
General description
D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.
Application
D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.
D-(+)-Galactosamine hydrochloride has been used:
- for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
- in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
- in mice for the generation of primary bone marrow-derived macrophages (BMDMs)
Biochem/physiol Actions
Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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