- Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
Bioorganic & medicinal chemistry letters (2008-07-16)
T D Venu, S A Khanum, Aiysha Firdouse, B K Manuprasad, Sheena Shashikanth, Riyaz Mohamed, Bannikuppe Sannanaik Vishwanth
PMID18621525
ABSTRACT
Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.