- Ruthenium(II)-catalyzed regioselective reductive coupling of α-imino esters with dienes.
Ruthenium(II)-catalyzed regioselective reductive coupling of α-imino esters with dienes.
Organic letters (2013-03-19)
Shujie Zhu, Xiaoxia Lu, Yueting Luo, Wei Zhang, Huanfeng Jiang, Ming Yan, Wei Zeng
PMID23496213
ABSTRACT
A method for the highly regioselective reductive coupling reaction of N-aryl-α-imino esters with dienes is described. The method utilizes the RuHCl(CO)(PPh3)3/iPrOH catalytic system under an Ar atmosphere and provides α-branched allylic α-amino acid derivatives. Application of this transformation to the concise synthesis of a natural plant growth regulator is demonstrated.